Neanderthals may have had a lower threshold for pain: People who inherited a special ion channel from Neanderthals experience more pain 

Nerve cells have a special ion channel that has a key role in starting the electrical impulse that signals pain and is sent to the brain. New research finds that people who inherited the Neanderthal variant of this ion channel experience more pain.

Source: Neanderthals may have had a lower threshold for pain: People who inherited a special ion channel from Neanderthals experience more pain — ScienceDaily

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